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CryoEM Structures and Atomic Model of the HIV-1 Strand Transfer Complex Intasome
HIV-1, like all retroviruses, irreversibly inserts a viral DNA (vDNA) copy of its RNA genome into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed of viral integrase (IN) and the ends of linear vDNA, mediates integration. Productive integration into host chromatin...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508583/ https://ncbi.nlm.nih.gov/pubmed/28059769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah5163 |
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