CryoEM Structures and Atomic Model of the HIV-1 Strand Transfer Complex Intasome

HIV-1, like all retroviruses, irreversibly inserts a viral DNA (vDNA) copy of its RNA genome into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed of viral integrase (IN) and the ends of linear vDNA, mediates integration. Productive integration into host chromatin...

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Publicado en:Science
Autores principales: Passos, Dario Oliveira, Li, Min, Yang, Renbin, Rebensburg, Stephanie V., Ghirlando, Rodolfo, Jeon, Youngmin, Shkriabai, Nikoloz, Kvaratskhelia, Mamuka, Craigie, Robert, Lyumkis, Dmitry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508583/
https://ncbi.nlm.nih.gov/pubmed/28059769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah5163
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