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Structural Basis for Strand Transfer Inhibitor Binding to HIV Intasomes
The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation of antiretrovirals, integrase (IN) strand transfer inhibitors (INSTIs). Challenges associated with lentiviral intaso...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7357238/ https://ncbi.nlm.nih.gov/pubmed/32001521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay8015 |
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