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Structural Basis for Strand Transfer Inhibitor Binding to HIV Intasomes

The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation of antiretrovirals, integrase (IN) strand transfer inhibitors (INSTIs). Challenges associated with lentiviral intaso...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Passos, Dario Oliveira, Li, Min, Jóźwik, Ilona K., Zhao, Xue Zhi, Santos-Martins, Diogo, Yang, Renbin, Smith, Steven J., Jeon, Youngmin, Forli, Stefano, Hughes, Stephen H., Burke, Terrence R., Craigie, Robert, Lyumkis, Dmitry
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357238/
https://ncbi.nlm.nih.gov/pubmed/32001521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay8015
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