Identification and molecular basis for SIRT6 loss-of-function point mutations in cancer

Chromatin factors have emerged as the most frequently affected family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether point mutations are selected for in cancer remains unclear. In this manuscript, we characterized naturally o...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kugel, Sita, Feldman, Jessica L., Klein, Mark A., Silberman, Dafne M., Sebastián, Carlos, Mermel, Craig, Dobersch, Stephanie, Clark, Abbe R., Getz, Gad, Denu, John M., Mostoslavsky, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618237/
https://ncbi.nlm.nih.gov/pubmed/26456828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.022
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