The Histone Deacetylase Sirt6 Controls Embryonic Stem Cell Fate Via Tet-Mediated Production of 5-Hydroxymethylcytosine

How embryonic stem cells (ESC) commit to specific cell lineages and ultimately yield all cell types of a fully formed organism remains a major question. ESC differentiation is accompanied by large-scale histone and DNA modifications, but the relations between these two categories of epigenetic chang...

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Publicado no:Nat Cell Biol
Main Authors: Etchegaray, Jean-Pierre, Chavez, Lukas, Huang, Yun, Ross, Kenneth N., Choi, Jiho, Martinez-Pastor, Barbara, Walsh, Ryan M., Sommer, Cesar A., Lienhard, Matthias, Kugel, Sita, Silberman, Dafne M., Ramaswamy, Sridhar, Mostoslavsky, Gustavo, Hochedlinger, Konrad, Goren, Alon, Rao, Anjana, Mostoslavsky, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593707/
https://ncbi.nlm.nih.gov/pubmed/25915124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3147
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