Attempts to restore scrapie prion infectivity after exposure to protein denaturants.

A wealth of experimental evidence argues that infectious prions are composed largely, if not entirely, of the scrapie isoform of the prion protein. We attempted to restore scrapie infectivity after exposure to protein denaturants including urea, chaotropic salts, and SDS. None of the procedures rest...

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Detalles Bibliográficos
Main Authors: Prusiner, S B, Groth, D, Serban, A, Stahl, N, Gabizon, R
Formato: Artigo
Idioma:Inglês
Publicado: 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC46182/
https://ncbi.nlm.nih.gov/pubmed/8464892
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