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Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems.

The scrapie prion protein (PrPSc) is derived from a cellular isoform (PrPC) that acquires protease resistance posttranslationally. We have used several different experimental approaches in attempts to reconstitute in vitro the processes leading to protease-resistant PrPSc molecules. In the first stu...

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Detalhes bibliográficos
Main Authors: Raeber, A J, Borchelt, D R, Scott, M, Prusiner, S B
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283664/
https://ncbi.nlm.nih.gov/pubmed/1356161
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