Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems.

The scrapie prion protein (PrPSc) is derived from a cellular isoform (PrPC) that acquires protease resistance posttranslationally. We have used several different experimental approaches in attempts to reconstitute in vitro the processes leading to protease-resistant PrPSc molecules. In the first stu...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Raeber, A J, Borchelt, D R, Scott, M, Prusiner, S B
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283664/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1356161/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.10.6155-6163.1992
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