Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems.

The scrapie prion protein (PrPSc) is derived from a cellular isoform (PrPC) that acquires protease resistance posttranslationally. We have used several different experimental approaches in attempts to reconstitute in vitro the processes leading to protease-resistant PrPSc molecules. In the first stu...

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Pubblicato in:	J Virol
Autori principali:	Raeber, A J, Borchelt, D R, Scott, M, Prusiner, S B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1356161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.10.6155-6163.1992
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