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Huntingtin N-terminal monomeric and multimeric structures destabilized by covalent modification of heteroatomic residues
Early-stage oligomer formation of the huntingtin protein may be driven by self-association of the seventeen-residue amphipathic α-helix at the protein’s N-terminus (Nt17). Oligomeric structures have been implicated in neuronal toxicity and may represent important neurotoxic species in Huntington’s d...
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| Vydáno v: | Biochemistry |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4617767/ https://ncbi.nlm.nih.gov/pubmed/26098795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00478 |
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