Toward optimization of AgoshRNA moleculesthat use a non-canonical RNAi pathway: Variations in the top and bottom base pairs

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism. The shRNA precursor is processed by Dicer into small interfering RNAs (siRNAs) and subsequently programs the RNAi-induced silencing complex (RISC) to find a complementary target mRNA (mR...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Herrera-Carrillo, Elena, Harwig, Alex, Berkhout, Ben
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615845/
https://ncbi.nlm.nih.gov/pubmed/25747107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1022024
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