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Toward optimization of AgoshRNA moleculesthat use a non-canonical RNAi pathway: Variations in the top and bottom base pairs

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism. The shRNA precursor is processed by Dicer into small interfering RNAs (siRNAs) and subsequently programs the RNAi-induced silencing complex (RISC) to find a complementary target mRNA (mR...

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Publicat a:RNA Biol
Autors principals: Herrera-Carrillo, Elena, Harwig, Alex, Berkhout, Ben
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615845/
https://ncbi.nlm.nih.gov/pubmed/25747107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1022024
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