Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity

Short hairpin RNAs (shRNAs) are widely used for gene silencing by the RNA interference (RNAi) mechanism. The shRNA precursor is processed by the Dicer enzyme into active small interfering RNAs (siRNAs) that subsequently target a complementary mRNA for cleavage by the Argonaute 2 (Ago2) complex. Rece...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:RNA Biol
Main Authors: Herrera-Carrillo, Elena, Harwig, Alex, Berkhout, Ben
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785215/
https://ncbi.nlm.nih.gov/pubmed/28569591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1328349
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