Boosting AgoshRNA activity by optimized 5’-terminal nucleotide selection

RNA interference (RNAi) can be triggered by synthetic small interfering RNAs (siRNAs) or transgene-expressed short hairpin RNAs (shRNAs). Recent evidence indicates that shRNA molecules, with a relatively short stem and small loop, are processed by Argonaute 2 protein (Ago2). We named these molecules...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Gao, Zongliang, Berkhout, Ben, Herrera-Carrillo, Elena
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546398/
https://ncbi.nlm.nih.gov/pubmed/30991896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1599259
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