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The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site

Recent evidence indicates that shRNAs with a relatively short basepaired stem do not require Dicer processing, but instead are processed by the Argonaute 2 protein (Ago2). We named these molecules AgoshRNAs as both their processing and silencing function are mediated by Ago2. This alternative proces...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Herrera-Carrillo, Elena, Gao, Zong-liang, Harwig, Alex, Heemskerk, Matthias T., Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397164/
https://ncbi.nlm.nih.gov/pubmed/27928054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1203
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