Comparison of Functional Variants in IFNL4 and IFNL3 for Association with Hepatitis C Virus Clearance

BACKGROUND & AIMS: Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls generation of the IFN-λ4 protein, is more strongly associated with HCV clearance than rs...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: O’Brien, Thomas R., Pfeiffer, Ruth M., Paquin, Ashley, Lang Kuhs, Krystle A., Chen, Sabrina, Bonkovsky, Herbert L., Edlin, Brian R., Howell, Charles D., Kirk, Gregory D., Kuniholm, Mark H., Morgan, Timothy R., Strickler, Howard D., Thomas, David L., Prokunina-Olsson, Ludmila
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615534/
https://ncbi.nlm.nih.gov/pubmed/26186989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.06.035
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