A variant upstream of IFNL3 (IL28B) creating a novel interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA-sequencing in primary human hepatocytes activated with synthetic dsRNA to mimic HCV infection. Upstream of IFNL3 (IL28B) on chromosome 19q13.13, we discovered a novel, transiently induced...

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Main Authors: Prokunina-Olsson, Ludmila, Muchmore, Brian, Tang, Wei, Pfeiffer, Ruth M., Park, Heiyoung, Dickensheets, Harold, Hergott, Dianna, Porter-Gill, Patricia, Mumy, Adam, Kohaar, Indu, Chen, Sabrina, Brand, Nathan, Tarway, McAnthony, Liu, Luyang, Sheikh, Faruk, Astemborski, Jacquie, Bonkovsky, Herbert L., Edlin, Brian R., Howell, Charles D., Morgan, Timothy R., Thomas, David L., Rehermann, Barbara, Donnelly, Raymond P., O’Brien, Thomas R.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793390/
https://ncbi.nlm.nih.gov/pubmed/23291588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2521
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