Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors

Non-small cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting tumor suppressor loss. Smad4 is an established tumor suppressor in pancreatic and colon cancer, however, the consequences of Smad4 loss in l...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Haeger, Sarah M., Thompson, Joshua J., Kalra, Sean, Cleaver, Timothy G., Merrick, Daniel, Wang, Xiao-Jing, Malkoski, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615192/
https://ncbi.nlm.nih.gov/pubmed/25893305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.112
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