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Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors
Non-small cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting tumor suppressor loss. Smad4 is an established tumor suppressor in pancreatic and colon cancer, however, the consequences of Smad4 loss in l...
Tallennettuna:
| Julkaisussa: | Oncogene |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4615192/ https://ncbi.nlm.nih.gov/pubmed/25893305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.112 |
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