Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Smad4 is a central mediator of TGF-β signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in g...

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Bibliografiske detaljer
Main Authors: Bornstein, Sophia, White, Ruth, Malkoski, Stephen, Oka, Masako, Han, Gangwen, Cleaver, Timothy, Reh, Douglas, Andersen, Peter, Gross, Neil, Olson, Susan, Deng, Chuxia, Lu, Shi-Long, Wang, Xiao-Jing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769185/
https://ncbi.nlm.nih.gov/pubmed/19841536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38854
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