Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Smad4 is a central mediator of TGF-β signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in g...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Bornstein, Sophia, White, Ruth, Malkoski, Stephen, Oka, Masako, Han, Gangwen, Cleaver, Timothy, Reh, Douglas, Andersen, Peter, Gross, Neil, Olson, Susan, Deng, Chuxia, Lu, Shi-Long, Wang, Xiao-Jing
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2009
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769185/
https://ncbi.nlm.nih.gov/pubmed/19841536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38854
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