Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Smad4 is a central mediator of TGF-β signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in g...

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Autori principali: Bornstein, Sophia, White, Ruth, Malkoski, Stephen, Oka, Masako, Han, Gangwen, Cleaver, Timothy, Reh, Douglas, Andersen, Peter, Gross, Neil, Olson, Susan, Deng, Chuxia, Lu, Shi-Long, Wang, Xiao-Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769185/
https://ncbi.nlm.nih.gov/pubmed/19841536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38854
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