Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Smad4 is a central mediator of TGF-β signaling, and its expression is downregulated or lost at the malignant stage in several cancer types. In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in g...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Bornstein, Sophia, White, Ruth, Malkoski, Stephen, Oka, Masako, Han, Gangwen, Cleaver, Timothy, Reh, Douglas, Andersen, Peter, Gross, Neil, Olson, Susan, Deng, Chuxia, Lu, Shi-Long, Wang, Xiao-Jing
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2009
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769185/
https://ncbi.nlm.nih.gov/pubmed/19841536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38854
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