Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure

The tumor suppressor, PTEN, is one of the most commonly mutated genes in cancer. Recently, PTEN has been shown to localize in the nucleus and is required to maintain genomic stability. Here, we show that nuclear PTEN, independent of its phosphatase activity, is essential for maintaining heterochroma...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Gong, Lili, Govan, Jeane M, Evans, Elizabeth B, Dai, Hui, Wang, Edward, Lee, Szu-Wei, Lin, Hui-Kuan, Lazar, Alexander J, Mills, Gordon B, Lin, Shiaw-Yih
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614552/
https://ncbi.nlm.nih.gov/pubmed/25946202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1044174
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires