Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure

The tumor suppressor, PTEN, is one of the most commonly mutated genes in cancer. Recently, PTEN has been shown to localize in the nucleus and is required to maintain genomic stability. Here, we show that nuclear PTEN, independent of its phosphatase activity, is essential for maintaining heterochroma...

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Publicado en:Cell Cycle
Main Authors: Gong, Lili, Govan, Jeane M, Evans, Elizabeth B, Dai, Hui, Wang, Edward, Lee, Szu-Wei, Lin, Hui-Kuan, Lazar, Alexander J, Mills, Gordon B, Lin, Shiaw-Yih
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
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Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614552/
https://ncbi.nlm.nih.gov/pubmed/25946202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1044174
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