Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Expression of PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms. In this study, we demonstrated that the Rak tyrosine kinase physically interacts with PTEN and phosphorylates PTEN on Tyr 336. The knockd...

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Detalhes bibliográficos
Main Authors: Yim, Eun-Kyoung, Peng, Guang, Dai, Hui, Hu, Ruozhen, Li, Kaiyi, Lu, Yiling, Mills, Gordon B., Meric-Bernstam, Funda, Hennessy, Bryan T., Craven, Rolf J., Lin, Shiaw-Yih
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673492/
https://ncbi.nlm.nih.gov/pubmed/19345329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.02.012
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