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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Expression of PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms. In this study, we demonstrated that the Rak tyrosine kinase physically interacts with PTEN and phosphorylates PTEN on Tyr 336. The knockd...

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Main Authors:	Yim, Eun-Kyoung, Peng, Guang, Dai, Hui, Hu, Ruozhen, Li, Kaiyi, Lu, Yiling, Mills, Gordon B., Meric-Bernstam, Funda, Hennessy, Bryan T., Craven, Rolf J., Lin, Shiaw-Yih
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2009
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2673492/ https://ncbi.nlm.nih.gov/pubmed/19345329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.02.012
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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

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