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Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing

Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical pro-tumorigenic role in cancer promoting angiogenesis and tumor cell survival. In this review we summarize pre-clinical evidence in support of the pro-tumorigenic fu...

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Vydáno v:Cancer Res
Hlavní autoři: Placencio, Veronica R., DeClerck, Yves A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613764/
https://ncbi.nlm.nih.gov/pubmed/26180080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0876
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