Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes

While insulin is an anabolic hormone, AMP-activated protein kinase (AMPK) is not only a key energy regulator, but it can also control substrate metabolism directly by inducing skeletal muscle protein degradation. The hypothesis of the present study was that insulin inhibits AMPK and thus down-regula...

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Vydáno v:Biosci Rep
Hlavní autoři: Deng, Hu-Ping, Chai, Jia-Ke, Shen, Chuan-An, Zhang, Xi-Bo, Ma, Li, Sun, Tian-Jun, Hu, Qing-Gang, Chi, Yun-Fei, Dong, Ning
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2015
Témata:
Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613693/
https://ncbi.nlm.nih.gov/pubmed/26193886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150017
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