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Regulation of apoptosis by XIAP ubiquitin-ligase activity
Inhibitor of Apoptosis Proteins (IAPs) can bind to and inhibit caspases, the key executioners of apoptosis. Because IAPs are frequently overexpressed in human tumors, they have become major pharmacological targets for developing new cancer therapeutics. However, the precise physiological function of...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518817/ https://ncbi.nlm.nih.gov/pubmed/18708583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1663108 |
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