Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes

In L6 myotubes, redistribution of a hemagglutinin (HA) epitope-tagged GLUT4 (HA-GLUT4) to the cell surface occurs rapidly in response to insulin stimulation and AMP-activated protein kinase (AMPK) activation. We have examined whether these separate signaling pathways have a convergent mechanism that...

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Detalhes bibliográficos
Main Authors: Fazakerley, Daniel J., Holman, Geoffrey D., Marley, Anna, James, David E., Stöckli, Jacqueline, Coster, Adelle C. F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804323/
https://ncbi.nlm.nih.gov/pubmed/19915010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051185
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