Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components

Cysteine string protein (CSP) is a chaperone of the Dnaj/Hsp40 family of proteins and is essential for synaptic maintenance. Mutations in the human gene encoding CSP, DNAJC5, cause adult neuronal ceroid lipofucinosis (ANCL) which is characterised by progressive dementia, movement disorders, seizures...

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Vydáno v:Sci Rep
Hlavní autoři: McCue, Hannah V., Chen, Xi, Barclay, Jeff W., Morgan, Alan, Burgoyne, Robert D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585785/
https://ncbi.nlm.nih.gov/pubmed/26395859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14392
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