Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol

Adult onset neuronal lipofuscinosis (ANCL) is a human neurodegenerative disorder characterized by progressive neuronal dysfunction and premature death. Recently, the mutations that cause ANCL were mapped to the DNAJC5 gene, which encodes cysteine string protein alpha. We show here that mutating dnj-...

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Detalhes bibliográficos
Main Authors: Kashyap, Sudhanva S., Johnson, James R., McCue, Hannah V., Chen, Xi, Edmonds, Matthew J., Ayala, Mimieveshiofuo, Graham, Margaret E., Jenn, Robert C., Barclay, Jeff W., Burgoyne, Robert D., Morgan, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204773/
https://ncbi.nlm.nih.gov/pubmed/24947438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu316
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