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The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4–Not nuclease module

In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4–Not deadenylase complex, which can be recruited to its target mRNA by RNA-binding proteins or the...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Maryati, Maryati, Airhihen, Blessing, Winkler, G. Sebastiaan
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613498/
https://ncbi.nlm.nih.gov/pubmed/25944446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150304
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