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1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg(2+)‐dependent binding

In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation. Using recombinant human Caf1 (CNOT7) enzyme as a screening tool, we...

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Библиографические подробности
Опубликовано в: :FEBS Open Bio
Главные авторы: Airhihen, Blessing, Pavanello, Lorenzo, Jadhav, Gopal P., Fischer, Peter M., Winkler, Gerlof Sebastiaan
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443996/
https://ncbi.nlm.nih.gov/pubmed/30984545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12605
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