The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

Receptor-interacting protein (RIP)3 is a critical regulator of necroptosis and has been demonstrated to be associated with various diseases, suggesting that its inhibitors are promising in the clinic. However, there have been few RIP3 inhibitors reported as yet. B-Raf(V600E) inhibitors are an import...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Li, J-X, Feng, J-M, Wang, Y, Li, X-H, Chen, X-X, Su, Y, Shen, Y-Y, Chen, Y, Xiong, B, Yang, C-H, Ding, J, Miao, Z-H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611716/
https://ncbi.nlm.nih.gov/pubmed/24901049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.241
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