The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

Receptor-interacting protein (RIP)3 is a critical regulator of necroptosis and has been demonstrated to be associated with various diseases, suggesting that its inhibitors are promising in the clinic. However, there have been few RIP3 inhibitors reported as yet. B-Raf(V600E) inhibitors are an import...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Li, J-X, Feng, J-M, Wang, Y, Li, X-H, Chen, X-X, Su, Y, Shen, Y-Y, Chen, Y, Xiong, B, Yang, C-H, Ding, J, Miao, Z-H
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611716/
https://ncbi.nlm.nih.gov/pubmed/24901049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.241
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