Kisspeptin Receptor Haplo-insufficiency Causes Premature Ovarian Failure Despite Preserved Gonadotropin Secretion

Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology remains uncertain. Whereas kisspeptins, the products of Kiss1 that act via Kiss1r (aka, Gpr54), are known to operate at the hypothalamus to control GnRH/gonadotropin secretion, additional actions at other repro...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Gaytan, Francisco, Garcia-Galiano, David, Dorfman, Mauricio D., Manfredi-Lozano, Maria, Castellano, Juan M., Dissen, Gregory A., Ojeda, Sergio R., Tena-Sempere, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611053/
https://ncbi.nlm.nih.gov/pubmed/24885574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1110
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