Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

Conditions of metabolic distress, from malnutrition to obesity, impact, via as yet ill-defined mechanisms, the timing of puberty, whose alterations can hamper later cardiometabolic health and even life expectancy. AMP-activated protein kinase (AMPK), the master cellular energy sensor activated in co...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Roa, Juan, Barroso, Alexia, Ruiz-Pino, Francisco, Vázquez, Maria Jesus, Seoane-Collazo, Patricia, Martínez-Sanchez, Noelia, García-Galiano, David, Ilhan, Tuncay, Pineda, Rafael, León, Silvia, Manfredi-Lozano, Maria, Heras, Violeta, Poutanen, Matti, Castellano, Juan M., Gaytan, Francisco, Diéguez, Carlos, Pinilla, Leonor, López, Miguel, Tena-Sempere, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233121/
https://ncbi.nlm.nih.gov/pubmed/30348767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802053115
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