Targeting the miR-221-222/PUMA/BAK/BAX pathway abrogates dexamethasone resistance in multiple myeloma

Despite recent therapeutic advances that have doubled the median survival time of patients with multiple myeloma (MM), intratumor genetic heterogeneity contributes to disease progression and emergence of drug resistance. MicroRNAs (miRs), are noncoding small RNAs that play important roles in the reg...

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Udgivet i:Cancer Res
Main Authors: Zhao, Jian-Jun, Chu, Zhang-Bo, Hu, Yu, Lin, Jianhong, Wang, Zhongqiu, Jiang, Meng, Chen, Ming, Wang, Xujun, Kang, Yue, Zhou, Yangsheng, Ni Chonghaile, Triona, Johncilla, Melanie E., Tai, Yu-Tzu, Cheng, Jin Q., Letai, Antony, Munshi, Nikhil C., Anderson, Kenneth C., Carrasco, Ruben D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609291/
https://ncbi.nlm.nih.gov/pubmed/26249174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0457
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