Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC

The fibroblast growth factor receptor FGFR1 is a therapeutic target under investigation in multiple solid tumors and clinical trials of selective tyrosine kinase inhibitors (TKI) are underway. Treatment with single TKI represents a logical step towards personalized cancer therapy, but intrinsic and...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Singleton, Katherine R., Hinz, Trista K., Kleczko, Emily K., Marek, Lindsay A., Kwak, Jeff, Harp, Taylor, Kim, Jihye, Tan, Aik Choon, Heasley, Lynn E.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609283/
https://ncbi.nlm.nih.gov/pubmed/26359452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0509
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