FGFR1 expression levels predict BGJ398-sensitivity of FGFR1-dependent head and neck squamous cell cancers

BACKGROUND: FGFR1 copy number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials. This study explores FGFR1 mRNA and protein levels in HNSCC cell lines, primary tumors and patient-derived xenografts (PDXs) as...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Göke, Friederike, Franzen, Alina, Hinz, Trista K., Marek, Lindsay A., Petros Yoon, Sharma, Rakesh, Bode, Maike, von Maessenhausen, Anne, Lankat-Buttgereit, Brigitte, Göke, Antonia, Golletz, Carsten, Kirsten, Robert, Boehm, Diana, Vogel, Wenzel, Kleczko, Emily K., Eagles, Justin R., Hirsch, Fred R., Van Bremen, Tobias, Bootz, Friedrich, Schroeck, Andreas, Kim, Jihye, Tan, Aik-Choon, Jimeno, Antonio, Heasley, Lynn E., Perner, Sven
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592392/
https://ncbi.nlm.nih.gov/pubmed/26015511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3357
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