Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model

Achondroplasia (ACH) is the most frequent form of dwarfism and is caused by gain-of-function mutations in the fibroblast growth factor receptor 3–encoding (FGFR3-encoding) gene. Although potential therapeutic strategies for ACH, which aim to reduce excessive FGFR3 activation, have emerged over many...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Komla-Ebri, Davide, Dambroise, Emilie, Kramer, Ina, Benoist-Lasselin, Catherine, Kaci, Nabil, Le Gall, Cindy, Martin, Ludovic, Busca, Patricia, Barbault, Florent, Graus-Porta, Diana, Munnich, Arnold, Kneissel, Michaela, Di Rocco, Federico, Biosse-Duplan, Martin, Legeai-Mallet, Laurence
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855917/
https://ncbi.nlm.nih.gov/pubmed/27064282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83926
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