An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall survival in head and neck cancer patients. We hypot...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Kleczko, Emily K., Kim, Jihye, Keysar, Stephen B., Heasley, Lydia R., Eagles, Justin R., Simon, Matthew, Marshall, Marianne E., Singleton, Katherine R., Jimeno, Antonio, Tan, Aik-Choon, Heasley, Lynn E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422719/
https://ncbi.nlm.nih.gov/pubmed/25946135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123600
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk