An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall survival in head and neck cancer patients. We hypot...

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Udgivet i:PLoS One
Main Authors: Kleczko, Emily K., Kim, Jihye, Keysar, Stephen B., Heasley, Lydia R., Eagles, Justin R., Simon, Matthew, Marshall, Marianne E., Singleton, Katherine R., Jimeno, Antonio, Tan, Aik-Choon, Heasley, Lynn E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422719/
https://ncbi.nlm.nih.gov/pubmed/25946135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123600
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