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Improving RNA-Seq expression estimation by modeling isoform- and exon-specific read sequencing rate

BACKGROUND: The high-throughput sequencing technology, RNA-Seq, has been widely used to quantify gene and isoform expression in the study of transcriptome in recent years. Accurate expression measurement from the millions or billions of short generated reads is obstructed by difficulties. One is amb...

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Bibliografski detalji
Izdano u:BMC Bioinformatics
Glavni autori: Liu, Xuejun, Shi, Xinxin, Chen, Chunlin, Zhang, Li
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609108/
https://ncbi.nlm.nih.gov/pubmed/26475308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0750-6
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