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Modeling Exon-Specific Bias Distribution Improves the Analysis of RNA-Seq Data

RNA-seq technology has become an important tool for quantifying the gene and transcript expression in transcriptome study. The two major difficulties for the gene and transcript expression quantification are the read mapping ambiguity and the overdispersion of the read distribution along reference s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Liu, Xuejun, Zhang, Li, Chen, Songcan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598124/
https://ncbi.nlm.nih.gov/pubmed/26448625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140032
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