Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting α(v)β(3) Integrin and VEGF Receptors**

A dual-action ligand targeting both integrin α(V)β(3) and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic α(V)β(3) Arg-Gly-Asp (RGD) ligand with a decapentapeptide. The latter was obtained from a known VEGFR antagonist by acetylation...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Zanella, Simone, Mingozzi, Michele, Dal Corso, Alberto, Fanelli, Roberto, Arosio, Daniela, Cosentino, Marco, Schembri, Laura, Marino, Franca, De Zotti, Marta, Formaggio, Fernando, Pignataro, Luca, Belvisi, Laura, Piarulli, Umberto, Gennari, Cesare
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608532/
https://ncbi.nlm.nih.gov/pubmed/26491644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201500062
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