Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

Although much is known about the molecular genetic mechanisms of autosomal-dominant polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we explore the in vivo effects of causal gene replacement in orthologous gene models of ADPKD in mice. Wild-type mice with huma...

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Dettagli Bibliografici
Pubblicato in:Am J Pathol
Autori principali: Li, Ao, Tian, Xin, Zhang, Xiaoli, Huang, Shunwei, Ma, Yujie, Wu, Dianqing, Moeckel, Gilbert, Somlo, Stefan, Wu, Guanqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2015
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607765/
https://ncbi.nlm.nih.gov/pubmed/26435415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.06.014
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