Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

Although much is known about the molecular genetic mechanisms of autosomal-dominant polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we explore the in vivo effects of causal gene replacement in orthologous gene models of ADPKD in mice. Wild-type mice with huma...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Li, Ao, Tian, Xin, Zhang, Xiaoli, Huang, Shunwei, Ma, Yujie, Wu, Dianqing, Moeckel, Gilbert, Somlo, Stefan, Wu, Guanqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607765/
https://ncbi.nlm.nih.gov/pubmed/26435415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.06.014
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