Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

Although much is known about the molecular genetic mechanisms of autosomal-dominant polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we explore the in vivo effects of causal gene replacement in orthologous gene models of ADPKD in mice. Wild-type mice with huma...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Am J Pathol
मुख्य लेखकों: Li, Ao, Tian, Xin, Zhang, Xiaoli, Huang, Shunwei, Ma, Yujie, Wu, Dianqing, Moeckel, Gilbert, Somlo, Stefan, Wu, Guanqing
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Investigative Pathology 2015
विषय:
Regular Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607765/
https://ncbi.nlm.nih.gov/pubmed/26435415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.06.014
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