Akt kinase-mediated checkpoint of cGAS DNA sensing pathway

Upon DNA stimulation, cyclic GMP-AMP synthetase (cGAS) synthesizes the second messenger cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon-β (IFN-β) production. However, it has remained undetermined how hosts regulate cGAS enzymatic activity after the resolution of DNA i...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Seo, Gil Ju, Yang, Aerin, Tan, Brandon, Kim, Sungyoon, Liang, Qiming, Choi, Younho, Yuan, Weiming, Feng, Pinghui, Park, Hee-Sung, Jung, Jae U.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607670/
https://ncbi.nlm.nih.gov/pubmed/26440888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.007
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