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Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells
Mitochondria play important roles in tumor cell physiology and survival by providing energy and metabolites for proliferation and metastasis. As part of their oncogenic status, cancer cells frequently produce increased levels of mitochondrial-generated reactive oxygen species (ROS). However, extensi...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607627/ https://ncbi.nlm.nih.gov/pubmed/26159482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.073 |
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