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Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction
Mitochondrial DNA (mtDNA) is essential for proper mitochondrial function and encodes 22 tRNAs, 2 rRNAs and 13 polypeptides that make up subunits of complex I, III, IV, in the electron transport chain and complex V, the ATP synthase. Although mitochondrial dysfunction has been implicated in processes...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3878289/ https://ncbi.nlm.nih.gov/pubmed/22766155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.002 |
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