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Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies

Mitochondrial-driven diseases encompass a diverse group of single-gene and complex disorders, all linked to mitochondrial dysfunction, with significant impacts on human health. While there are rare mitochondrial diseases in which the primary defect resides in mutations in mitochondrial DNA, it is in...

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Autori principali: Dalia M. Miller, Stephen L. Archer, Kimberly J. Dunham-Snary
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-06-01
Serie:Frontiers in Aging
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Accesso online:https://www.frontiersin.org/articles/10.3389/fragi.2025.1585508/full
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